Recombinant Human MAPK14/p38 alpha, Active CRP277B from Cell Sciences

Description

MAPK14/p38 alpha is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines. The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response

Product Specs
ItemRecombinant Human MAPK14/p38 alpha, Active
CompanyCell Sciences
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberCRP277B
SpeciesHuman
Source/Expression SystemSf9 cells
Quantity10 µg
Molecule NameMAPK14
Activity> 150 nmol/min/mg:, by Kinase Specific Activity: nmol phosphate incorporated into the PKB-sub peptide (CKRPRAASFAE) per minute per mg protein at 30ºC for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay)
Format50 mM Tris-HCl, 150 mM NaCl, 10 mM glutathoine, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% Glycerol, pH 7.5
Purity>90% by SDS-PAGE (Coomassie)
TypeProteins, Kinases
Molecular Weight~67 kDa
NCBI Full Gene Namemitogen-activated protein kinase 14
NCBI Gene AliasesEXIP, CSBP1, Mxi2, CSBP2, p38ALPHA, CSBP, p38, SAPK2A, RK, CSPB1, PRKM15, PRKM14